Reviewed by Russell Noga, Licensed Medicare Insurance Broker (all 50 states) — Last updated October 30, 2026
Mayo Clinic, MD Anderson Cancer Center and Moffitt Cancer Center all accept Original Medicare, but each one is in network with only a short list of Medicare Advantage plans. Over the past two years, all three have dropped or lost contracts with some of the largest Medicare Advantage insurers, including UnitedHealthcare, Humana, Aetna and Blue Cross Blue Shield of Texas.
If you want one of these centers available for a future diagnosis, the plan you pick during Open Enrollment (October 15 to December 7, 2026) matters more than usual. Below is what each center lists today, what changed recently, and what our analysis of CMS 2027 plan data shows about the counties around each campus.


